Effect of Multifunctional Cationic Polymer Coatings on Mitigation of Broad Microbial Pathogens
Jianliang Gong, Chun-Yin Or, Eric Tung-Po Sze, Sidney Man-Ngai Chan, Pak-Long Wu, Peggy Miu-Yee Poon, Anthony K Y Law, Lucie Ulrychová, Jan Hodek, Jan Weber, Hui Ouyang, My Yang, Stephanie M Eilts, Montserrat Torremorell, Yaakov Knobloch, Christopher J Hogan, Christine Atallah, Juliette Davies, John Winkler, Ryan Gordon, Reza Zarghanishiraz, Mojtaba Zabihi, Cole Christianson, Deanne Taylor, Alan Rabinowitz, Jared Baylis, Joshua Brinkerhoff, Jonathan P Little, Ri Li, Jeanne Moldenhauer, Michael K Mansour
Infection control measures to prevent viral and bacterial infection spread are critical to maintaining a healthy environment. Pathogens such as viruses and pyogenic bacteria can cause infectious complications. Viruses such as SARS-CoV-2 are known to spread through the aerosol route and on fomite surfaces, lasting for a prolonged time in the environment. Developing technologies to mitigate the spread of pathogens through airborne routes and on surfaces is critical, especially for patients at high risk for infectious complications. Multifunctional coatings with a broad capacity to bind pathogens that result in inactivation can disrupt infectious spread through aerosol and inanimate surface spread. This study uses C-POLAR, a proprietary cationic, polyamine, organic polymer with a charged, dielectric property coated onto air filtration material and textiles. Using both SARS-CoV-2 live viral particles and bovine coronavirus models, C-POLAR-treated material shows a dramatic 2-log reduction in circulating viral inoculum. This reduction is consistent in a static room model, indicating simple airflow through a static C-POLAR hanging can capture significant airborne particles. Finally, Gram-positive and Gram-negative bacteria are applied to C-POLAR textiles using a viability indicator to demonstrate eradication on fomite surfaces. These data suggest that a cationic polymer surface can capture and eradicate human pathogens, potentially interrupting the infectious spread for a more resilient environment.
This article was co-authored by Dr Sidney CHAN Man-ngai of School of Science and Technology, HKMU.
(Excerpt from the article abstract)