Staff Profile

Teaching Areas & Research Interests

• Diagnostic applications of molecular profiling, genotyping, and genetic variation analysis, particularly of utilizing short- and long-read sequencing technologies, in human diseases
• Study of underlying mechanisms for the development and manifestation of human diseases and cancers

Academic & Professional Experience

Supplementary Medical Professions Council:

• Member of the Registration Committee

Hong Kong Medical Laboratory Technologists (HK MLT) Board 

• Board Member
• Chairman of the Registration Committee
• Member of the Examination Committee

Hong Kong Laboratory Accreditation Scheme (HOKLAS)

• Medical Laboratory Assessor

Journal Editors:

• Academic Editor, PLoS One
• Associate Editor for BMC Medical Genomics
• Associate Editor and Review Editor for Frontiers in Genetics (Human and Medical Genomics)
• Review Editor for Frontiers in Pediatrics (Genetics of Common and Rare Diseases)
• Editorial Board for Scient Open Access, Women's Health & Gynecology
• Guest Editor for Diagnostics, MDPI

Other Honorary Appointments:

• Honorary Assistant Professor (Department of Pathology, HKU)
• Honorary Research Fellow (Department of Pathology, HKU-ShenZhen Hospital)

Selected Publications

Journal Articles

• Published 110 papers and reviews in peer-reviewed and international journals, including Nature Genetics, Nature Communication, Cancer Research, PLOS Genetics, PLOS One, NPJ Genomic Medicine, Prenatal Diagnosis, and American Journal of Medical Genetics (Part A and C). Scopus Author Identifier: 7406034195 (Holding H-index of 34 and total of citations 3279 times, as of 4 Jan 2024.
• Hong L, Tang MHY, Cheung KW, Luo L, Cheung CKY, Dai X, Li Y, Xiong C, Liang W, Xiang W, Wang L, Chan KYK*, Lin S*. Fetal Hyperthyroidism with Maternal Hypothyroidism: Two Cases of Intrauterine Therapy. Diagnostics (Basel). 2024, Jan 03;14(1):102. PMID:38201411. *corresponding author.
• Khan SA, Chan KYK*, Lee TKW*. Global trajectory and future prospects of metronomic chemotherapy research: A scientometric analysis (2000-2022). Cancer Lett. 2023 Sep 27;576:216401. Epub ahead of print. PMID: 37774827. *corresponding author.
• Lee M, Kwong AKY, Chui MMC, Chau JFT, Mak CCY, Au SLK, Lo HM, Chan KYK, Yépez VA, Gagneur J, Kan ASY, Chung BHY. Diagnostic potential of the amniotic fluid cells transcriptome in deciphering mendelian disease: a proof-of-concept. NPJ Genom Med. 2022 Dec 28;7(1):74.
• Lai THT, Au LKS, Lau YTE, Lo HM, Chan KYK, Cheung KW, Ma TWL, Leung WC, Kong CW, Shu W, So PL, Kwong AKY, Mak CCY, Lee M, Chui MMC, Chung BHY, Kan ASY. Application of Prenatal Whole Exome Sequencing for Structural Congenital Anomalies-Experience from a Local Prenatal Diagnostic Laboratory. Healthcare. 2022 Dec 13;10(12):2521
• Yu PT, Shu W, Mok SL, Hui PW, Chan LW, Kwok KY, Chan KYK, Lo TK, Chung BHY, Luk HM, Kan ASY. Prenatal presentation in two fetuses with features of Beckwith Wiedemann syndrome-An unexpected diagnosis of androgenetic chimera and its clinical implications. Am J Med Genet A. 2022 May;188(5):1562-156
• Chau JFT, Yu MHC, Chui MMC, Yeung CCW, Kwok AWC, Zhuang X, Lee R, Fung JLF, Lee M, Mak CCY, Ng NYT, Chung CCY, Chan MCY, Tsang MHY, Chan JCK, Chan KYK, Kan ASY, Chung PHY, Yang W, Lee SL, Chan GCF, Tam PKH, Lau YL, Yeung KS, Chung BHY, Tang CSM. Comprehensive analysis of recessive carrier status using exome and genome sequencing data in 1543 Southern Chinese. NPJ Genom Med. 2022 Mar 21;7(1):23.
• Yu FNY, Li EYY, Kong MCW, Ma TWL, Chan KYK, Man E, Chung BHY, Kan ASY. Increasing prenatal diagnosis of chimeras with the use of noninvasive prenatal screening: Report of two cases. Prenat Diagn. 2021 May;41(6):697-700.
• Yu MHC, Chau JFT, Au SLK, Lo HM, Yeung KS, Fung JLF, Mak CCY, Chung CCY, Chan KYK, Chung BHY, Kan ASY. Evaluating the Clinical Utility of Genome Sequencing for Cytogenetically Balanced Chromosomal Abnormalities in Prenatal Diagnosis. Front Genet. 2021 Jan 27;11:620162
• Tung JY, Lai SHY, Au SLK, Yeung KS, Kan ASY, Loong F, DeLeón DD, Kalish JM, Ganguly A, Chung BHY, Chan KYK*. Coexistence of paternally-inherited ABCC8 mutation and mosaic paternal uniparental disomy 11p hyperinsulinism. Int J Pediatr Endocrinol. 2020;2020:13. * corresponding author.
• Shu X, Long J, Cai Q, Kweon SS, Choi JY, Kubo M, Park SK, Bolla MK, Dennis J, Wang Q, Yang Y, Shi J, Guo X, Li B, Tao R, Aronson KJ, Chan KYK, Chan TL, Gao YT, Hartman M, Kee Ho W, Ito H, Iwasaki M, Iwata H, John EM, Kasuga Y, Soon Khoo U, Kim MK, Kong SY, Kurian AW, Kwong A, Lee ES, Li J, Lophatananon A, Low SK, Mariapun S, Matsuda K, Matsuo K, Muir K, Noh DY, Park B, Park MH, Shen CY, Shin MH, Spinelli JJ, Takahashi A, Tseng C, Tsugane S, Wu AH, Xiang YB, Yamaji T, Zheng Y, Milne RL, Dunning AM, Pharoah PDP, García-Closas M, Teo SH, Shu XO, Kang D, Easton DF, Simard J, Zheng W. Identification of novel breast cancer susceptibility loci in meta-analyses conducted among Asian and European descendants. Nat Commun. 2020 Mar 5;11(1):1217.
• Chung CCY*, Chan KYK*, Hui PW, Au PKC, Tam WK, Li SKM, Leung GKC, Fung JLF, Chan MCY, Luk HM, Mak ASL, Leung KY, Tang MHY, Chung BHY, Kan ASY. Cost-effectiveness analysis of chromosomal microarray as a primary test for prenatal diagnosis in Hong Kong. BMC Pregnancy Childbirth. 2020 Feb 14;20(1):109. * authors equally contributed to this work.
• Chan KYK, Au SLK, Kan ASY. Development of cytogenomics for prenatal diagnosis: from chromosomes to single nucleotides: a review. Hong Kong J Gynaecol Obstet Midwifery. 2019; 19(2):114-22.
• Cheng SSW, Chan KYK, Leung KKP, Au PKC, Tam WK, Li SKM, Luk HM, Kan ASY, Chung BHY, Lo IFM, Tang MHY. Experience of chromosomal microarray applied in prenatal and postnatal settings in Hong Kong. Am J Med Genet C Semin Med Genet. 2019 Jun;181(2):196-207.
• Mak A, Lee H, Poon CF, Kwok SL, Ma T, Chan KYK, Kan A, Tang M, Leung KY. Factors associated with common and atypical chromosome abnormalities after positive combined first-trimester screening in Chinese women: a retrospective cohort study. BMC Pregnancy Childbirth. 2019 Feb 4;19(1):55.
• Lo TK, Chan KY, Kan AS, So PL, Kong CW, Mak SL, Lee CN. Informed choice and decision making in women offered cell-free DNA prenatal genetic screening. Prenat Diagn. 2017 Mar;37(3):299-302
• Leung WC, Lau WL, Lo TK, Lau TK, Lam YY, Kan A, Chan K, Lau ET, Tang MH. Two IUGR foetuses with maternal uniparental disomy of chromosome 6 or UPD(6)mat. J Obstet Gynaecol. 2016 Dec 6:1-3
• Kan AK, Chan KY. Chapter 3: Role of chromosomal microarray in prenatal diagnosis. The Hong Kong Medical Diary. 2015 Oct 20(10):20-24.
• Kwok HF, Zhang SD, McCrudden CM, Yuen HF, Ting KP, Wen Q, Khoo US, Chan KY. Prognostic significance of minichromosome maintenance proteins in breast cancer. Am J Cancer Res. 2014 Dec 15;5(1):52-71.
• Cai Q, Zhang B, Sung H, Low SK, Kweon SS, Lu W, Shi J, Long J, Wen W, Choi JY, Noh DY, Shen CY, Matsuo K, Teo SH, Kim MK, Khoo US, Iwasaki M, Hartman M, Takahashi A, Ashikawa K, Matsuda K, Shin MH, Park MH, Zheng Y, Xiang YB, Ji BT, Park SK, Wu PE, Hsiung CN, Ito H, Kasuga Y, Kang P, Mariapun S, Ahn SH, Kang HS, Chan KY, Man EP, Iwata H, Tsugane S, Miao H, Liao J, Nakamura Y, Kubo M; DRIVE GAME-ON Consortium, Delahanty RJ, Zhang Y, Li B, Li C, Gao YT, Shu XO, Kang D, Zheng W Genome-wide association analysis in East Asians identifies breast cancer susceptibility loci at 1q32.1, 5q14.3 and 15q26.1. Nat Genet. 2014 Aug;46(8):886-90.
• Zhang L, Gong C, Lau SL, Yang N, Wong OG, Cheung AN, Tsang JW, Chan KY, Khoo US. SpliceArray profiling of breast cancer reveals a novel variant of NCOR2/SMRT that is associated with tamoxifen resistance and control of ERα transcriptional activity. Cancer Res. 2013 Jan 1;73(1):246-55
• Long J, Cai Q, Sung H, Shi J, Zhang B, Choi JY, Wen W, Delahanty RJ, Lu W, Gao YT, Shen H, Park SK, Chen K, Shen CY, Ren Z, Haiman CA, Matsuo K, Kim MK, Khoo US, Iwasaki M, Zheng Y, Xiang YB, Gu K, Rothman N, Wang W, Hu Z, Liu Y, Yoo KY, Noh DY, Han BG, Lee MH, Zheng H, Zhang L, Wu PE, Shieh YL, Chan SY, Wang S, Xie X, Kim SW, Henderson BE, Le Marchand L, Ito H, Kasuga Y, Ahn SH, Kang HS, Chan KY, Iwata H, Tsugane S, Li C, Shu XO, Kang DH, Zheng W. Genome-wide association study in east Asians identifies novel susceptibility loci for breast cancer. PLoS Genet. 2012. Feb;8(2): e1002532.
• Chan KY*, Wong CM*, Kwan JS*, Lee JM, Cheung KW, Yuen MF, Lai CL, Poon RT, Sham PC, Ng IO. Genome-wide association study of hepatocellular carcinoma in southern chinese patients with chronic hepatitis B virus infection. PLoS One. 2011;6(12):e28798. PMID: 22174901. * authors equally contributed to this work.
• Liu SS, Chan KY, Leung RC, Chan KK, Tam KF, Luk MH, Lo SS, Fong DY, Cheung AN, Lin ZQ, Ngan HY. Prevalence and risk factors of Human Papillomavirus (HPV) infection in southern Chinese women - a population-based study. PLoS One. 2011 May 3;6(5):e19244.
• Chan VS*, Chan KY*, Chen Y*, Poon LL, Cheung AN, Zheng B, Chan KH, Mak W, Ngan HY, Xu X, Screaton G, Tam PK, Austyn JM, Chan LC, Yip SP, Peiris M, Khoo US, Lin CL. Homozygous L-SIGN (CLEC4M) plays a protective role in SARS coronavirus infection. Nat Genet. 2006 Jan;38(1):38-46. * authors equally contributed to this work.

Selected Professional & Community Services

• Supplementary Medical Professions Council: Member of the Registration Committee
• Hong Kong Medical Laboratory Technologists (MLT) Board: Board Member; Chairman of the Registration Committee; Member of the Examination Committee
• Hong Kong Laboratory Accreditation Scheme (HOKLAS): Medical Laboratory Assessor

Further Information

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Modified Date: 19 Jan, 2024
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