Biography
Dr Tang received his PhD in the LKS Faculty of Medicine from the University of Hong Kong. He was then awarded American Heart Association Postdoctoral Fellowship to continue studies at Yale University Cardiovascular Research Center in the United States. Dr Tang is the Head of the Department of Diagnostic Sciences and Professor of the School of Nursing and Health Sciences at Hong Kong Metropolitan University. He also serves as Principal Investigator at Guangzhou Medical University. His laboratory has been focusing on the platelet heterogeneity in cardiovascular diseases. He has also been investigating the mechanism underlying the intercellular transfer of platelet microRNAs and their potential application as biomarkers for disease. His research has been supported by the National Natural Science Foundation of China, the Guangdong Natural Science Foundation, and the Hong Kong University Grants Committee etc.
Teaching Areas & Research Interests
- Vascular biology and therapeutic applications of platelets
- Pathogenesis of cardiovascular and metabolic diseases
Academic & Professional Experience
08/2023-Present Professor, School of Nursing & Health Sciences, Hong Kong Metropolitan University
08/2023-Present Principal Investigator, Guangzhou Medical University
07/2015-07/2023 Professor, Guangzhou Medical University
07/2015-07/2023 Associate Director & Principal Investigator, Guangzhou Institute of Pediatrics, Guangzhou Women and Children Medical Center
07/2014-07/2015 Associate Research Scientist, Yale School of Medicine, Yale University
Selected Publications
Journal Articles
- Wen Y, Liu Y, Li Q, Tan J, Fu X, Liang Y, Tuo Y, Liu L, Zhou X, LiuFu D, Fan
X, Chen C, Chen Z, Wang Z, Fan S, Liu R, Pan L, Zhang Y, Tang WH. Spatiotemporal
ATF3 Expression Determines VSMC Fate in Abdominal Aortic Aneurysm. Circ Res.
2024;134(11):1495-1511. doi: 10.1161/CIRCRESAHA.124.324323.
- Su M, Chen C, Li S, Li M, Zeng Z, Zhang Y, Xia L, Li X, Zheng D, Lin Q, Fan X, Wen Y, Liu Y, Chen F, Luo W, Bu Y, Qin J, Guo M, Qiu M, Sun L, Liu R, Wang P, Hwa J, Tang WH. Gasdermin D-dependent platelet pyroptosis exacerbates NET formation and inflammation in severe sepsis. Nat Cardiovasc Res. 2022; 1:732-747. doi: 10.1038/s44161-022-00108-7
- Guo M, Fan S, Chen Q, Jia C, Qiu M, Bu Y, Tang WH, Zhang Y. Platelet-derived
microRNA-223 attenuates TNF-α induced monocytes adhesion to arterial endothelium
by targeting ICAM-1 in Kawasaki disease. Front Immunol. 2022; 13:922868.
doi: 10.3389/fimmu.2022.922868.
- Zeng Z, Xia L, Fan S, Zheng J, Qin J, Fan X, Liu Y, Tao J, Liu Y, Li K, Ling Z, Bu Y, Martin KA, Hwa J, Liu R, Tang WH. Circular RNA CircMAP3K5 Acts as a MicroRNA-22-3p Sponge to Promote Resolution of Intimal Hyperplasia Via TET2-Mediated Smooth Muscle Cell Differentiation. Circulation. 2021; 143:354-371. doi: 10.1161/CIRCULATIONAHA.120.049715.
- Zhang Y, Wang Y, Zhang L, Xia L, Zheng M, Zeng Z, Liu Y, Yarovinsky T, Ostriker AC, Fan X, Weng K, Su M, Huang P, Martin KA, Hwa J, Tang WH. Reduced Platelet miR-223 Induction in Kawasaki Disease Leads to Severe Coronary Artery Pathology Through a miR-223/PDGFRbeta Vascular Smooth Muscle Cell Axis. Circ Res. 2020; 127:855-873. doi: 10.1161/CIRCRESAHA.120.316951.
- Zeng Z, Xia L, Fan X, Ostriker AC, Yarovinsky T, Su M, Zhang Y, Peng X, Xie Y, Pi L, Gu X, Chung SK, Martin KA, Liu R, Hwa J, Tang WH. Platelet-derived miR-223 promotes a phenotypic switch in arterial injury repair. J Clin Invest. 2019; 129:1372-1386. doi: 10.1172/JCI124508.
- Huang B, Chen Z, Geng L, Wang J, Liang H, Cao Y, Chen H, Huang W, Su M, Wang H, Xu Y, Liu Y, Lu B, Xian H, Li H, Li H, Ren L, Xie J, Ye L, Wang H, Zhao J, Chen P, Zhang L, Zhao S, Zhang T, Xu B, Che D, Si W, Gu X, Zeng L, Wang Y, Li D, Zhan Y, Delfouneso D, Lew AM, Cui J, Tang WH, Zhang Y, Gong S, Bai F, Yang M, Zhang Y. Mucosal Profiling of Pediatric-Onset Colitis and IBD Reveals Common Pathogenics and Therapeutic Pathways. Cell. 2019; 179(5):1160-1176.e24. doi: 10.1016/j.cell.2019.10.027.
- Lee SH, Du J, Stitham J, Atteya G, Lee S, Xiang Y, Wang D, Jin Y, Leslie KL, Spollett G, Srivastava A, Mannam P, Ostriker A, Martin KA, Tang WH, Hwa J. Inducing mitophagy in diabetic platelets protects against severe oxidative stress. EMBO Mol Med. 2016; 8(7):779-95. doi: 10. 15252/emmm.201506046.
- Tang WH, Stitham J, Jin Y, Liu R, Lee SH, Du J, Atteya G, Gleim S, Spollett G, Martin K, Hwa J. Aldose reductase-mediated phosphorylation of p53 leads to mitochondrial dysfunction and damage in diabetic platelets. Circulation. 2014; 129(15):1598- 609. doi: 10. 1161/CIRCULATIONAHA. 113.005224.
- Liu R, Jin Y, Tang WH, Qin L, Zhang X, Tellides G, Hwa J, Yu J, Martin KA. Ten- eleven translocation-2 (TET2) is a master regulator of smooth muscle cell plasticity. Circulation. 2013; 128(18):2047-57. doi: 10. 1161/CIRCULATIONAHA. 113.002887.
Selected Professional & Community Services
- Reviewer of Frontiers in Cardiovascular Medicine
- Reviewer of Frontiers in Cardiovascular Metabolism
Modified Date: 04 Dec, 2025
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